Thursday, September 17, 2026 at 8:15 PM EDT
Detroit Lions visit Buffalo Bills in Week 2 of the 2026 NFL season. They meet at Highmark Stadium in Orchard Park, NY, with Prime Video carrying the broadcast. DET come in at 1-0, BUF at 1-0. The market has BUF -4.5 with a total of 54.5. It opened BUF -3.
Lines via DraftKings. Odds shown for reference only.
Nothing has been attached to this matchup yet. The systems and trends that qualify, and the full breakdown once it is written, land here as the week fills in — check back closer to kickoff.
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